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KMID : 0613319990050020095
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Journal of the Korean Bone and Joint Tumor Soceity
1999 Volume.5 No. 2 p.95 ~ p.104
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Microvessel Count and the Expression of Ki-67 and p53 Protein according to Pathologic Grading in Soft Tissue Sarcoma
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Kim Yoo-Jin
Seo Ji-Young
Kim Soon-Young
Kim Kyo-Hyeon
Huh Bang
Chang Hee-Kyung
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Abstract
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Soft-tissue sarcoma is a malignant tumor characterized by a diverse biologic behavioral pattern and a wide range of morphologic features. Several studies haute implicated tumor size, location, morphologic classification, and the presence of metastases as prognostic factors. However, they do not always provide sufficient information for predicting the clinical course. This study evaluated the relationship of Ki-67, p53, and Factor Ⅷ expression to the histologic grades of 39 cases of soft tissue sarcomas using immunohistochemistry, since they have been currently proposed as prognostic factors. The histologic grade of soft tissue sarcoma was established according to the FNCLCC (Federation Nationals des Centres de Lutte Contre de Cancer) system, retrospectively. Ki-67, p53, and Factor Ⅷ expression were immunohistochemically analyzed in formalin-fixed and paraffin-embedded tissues from soft-tissue sarcomas in order to evaluate the correlation between the expression of each antibody and histologic grade and also between antibodies. Increased Ki-67 expression correlated positively with high histologic grade, poor differentiation, and high mitotic count (p<0.05). The sarcomas with high expression of Ki-67 seemed to show a high level of p53 expression, but its statistical significance was not found. p53 expression in soft-tissue sarcomas was only associated with mitotic count, but not with histologic grade, degree of cell differentiation, and necrosis. There was no relationship between microvessel count quantified by Factor Ⅷ expression and histologic variances, Ki-67, and p53 expression. These results suggest that the evaluation of Ki-67 expression should be considered as an easier and more objective method for determining prognoses of soft-tissue sarcomas. However, a large scale study with extensive follow-up is required to establish Ki-67 expression as a prognostic factor.
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KEYWORD
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Soft tissue sarcomas, Histologic grade, Ki-67, p53, Microvessel count
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